Augmented Multimodal Neurologic Monitoring in High Risk Survivors of Cardiac Arrest
Stopped early · Not applicable
Conditions studied: Cardiac Arrest
In brief
Cardiac arrest is the most common cause of death in the United States and as many as 590,000 Americans suffering a cardiac arrest each year. Despite advances in care, as many as 50 to 89% of patients who are resuscitated after a cardiac arrest die in the hospital. Brain injury is the most common cause of death and disability after cardiac arrest. The investigators use advanced brain monitoring in patients who are at high risk of death after cardiac arrest, with the goal of preventing ongoing brain injury. The most common problem the investigators have observed is low oxygen levels in the brain, which is often very difficult to treat. In this study, the investigators plan to use two additional brain monitors in the care of these high risk patients: a monitor for seizures and a monitor of the amount of blood flow in the brain. The investigators will use these to detect and treat potential causes of low brain oxygen levels. The main hypotheses are that electrical events in the brain such as seizures and "spreading depolarizations" will occur during times of low brain tissue oxygen level, and that treating these events and low blood flow will reduce the rate of low brain oxygen levels.
Key facts
- Study ID
- NCT02069353
- Run by
- Jonathan Elmer
- People needed
- 4
- Starts
- 2015-07-01
- Expected to finish
- 2018-10-19
- Last updated by the study team
- 2019-10-08
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- High risk survivors of cardiac arrest
- Decision by potential subject's clinical team to use our institutional standard invasive, multimodal neurologic monitoring for post-arrest care
You may not qualify if…
- None
Where it is running
- University of Pittsburgh — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
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