IV Acetaminophen for Acute Post Operative Pain in C-Section Patients

Completed · Phase 4 · Has a placebo group

Conditions studied: Post-operative Pain

In brief

Post-operative pain management after C-section is an important topic as the number of elective c-sections increases each year. Pain is managed either by giving opioids or by using non-opioids. The purpose of this study is to evaluate the effectiveness of IV Acetaminophen in pain relief and its impact in the usage of post-operative opioid requirements and opioid associated complications. The hypothesis is that four doses of IV Acetaminophen in conjunction with intrathecal or epidural morphine given to the patients after c-section will reduce post-operative opioid requirements and opioid associated complications.

Key facts

Study ID

NCT02069184

Run by

Montefiore Medical Center

People needed

66

Starts

2013-11-01

Expected to finish

2014-12-01

Last updated by the study team

2019-08-22

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Elective full term CS patients
• Age 18 and above
• ASA I-III

You may not qualify if…

• Allergic reaction to IV acetaminophen
• Not able to understand and sign the research consent
• Pregnancy induced hypertension or pre-eclampsia patients
• Planned intensive care admission patients
• Patients with severe hepatic impairment or active liver diseases (Two fold increase in any of the liver enzymes)
• Patients with serum creatinine>2mg/dl
• For nursing mothers, any evidence of hepatic dysfunction of the new born

Where it is running

• Montefiore Medical Center- Weiler — The Bronx, New York, United States

Full record on ClinicalTrials.gov

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