Effects of Epicatechin on Functional Capacity, Skeletal Muscle Structure and Diastolic Function in Patients With Heart Failure With Preserved Ejection Fraction (HFPEF)

Completed · Not applicable

Conditions studied: Heart Failure

In brief

The major goal of this proposal is to characterize the ability of epicatechin which a component of dark chocolate to improve the 1. structural and functional features of skeletal muscle (SkM) 2. exercise capacity (as assessed by VO2 max) 3. parameters of diastolic heart function (as assessed by echocardiography) We propose that a 3 month treatment with epicatechin (through CocoaVia® capsules) will lead to a significant improvement in exercise capacity and diastolic function.

Key facts

Study ID

NCT02068040

Run by

University of California, San Diego

People needed

7

Starts

2014-01-01

Expected to finish

2015-04-01

Last updated by the study team

2015-06-03

Who can join

Age: 40 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Medically Diagnosed Heart Failure with Ejection Fraction of >55%
• BMI 27-32
• No Significant HbA1C fluctuations in past 6 months

You may not qualify if…

• Smoking or quit smoking less than 1 year prior to enrollment
• Substance Abuse
• Taking Coudmadin or Pradaxa

Where it is running

• University of California, San Diego — La Jolla, California, United States

Full record on ClinicalTrials.gov

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