Analysis of Aqueous and Vitreous Humor

Status unconfirmed · Phase 2

Conditions studied: Proliferative Diabetic Retinopathy, Macular Degeneration, Macular Hole, Neovascular Glaucoma

In brief

Clinical Retina research studies often collect aqueous samples in hopes of estimating levels of drug or cytokines in the vitreous. Little is known about how well vitreous and aqueous correlate. This study will collect vitreous and aqueous samples at the same time to evaluate and compare drug and cytokine levels. The overall objective of this study is to evaluate the molecular concentration of growth factors, cytokines and chemokines in human aqueous humor and vitreous samples collected from individuals undergoing pars plana vitrectomy for tractional retinal detachment secondary to proliferative diabetic retinopathy, exudative or tractional retinal detachment secondary to macular degeneration, macular hole or neovascular glaucoma.

Key facts

Study ID

NCT02067013

Run by

California Retina Consultants

People needed

45

Starts

2015-07-01

Expected to finish

2017-07-01

Last updated by the study team

2017-03-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ability to provide written informed consent and comply with study assessments for the full duration of the study
• Age > 18 years
• Subjects with a diagnosis of tractional retinal detachment secondary to proliferative diabetic retinopathy, age-related macular degeneration with tractional or exudative retinal detachment, macular hole, epiretinal membrane, or neovascular glaucoma.

You may not qualify if…

• Subjects with history of vitrectomy in the study eye
• Presence of vitreous hemorrhage
• Subjects with history of laser photocoagulation in the study eye within 3 months of vitrectomy
• Subjects unwilling to undergo pars plana vitrectomy
• Subjects unwilling to receive intravitreal ranibizumab prior to pars plana vitrectomy unless diagnosis of macular hole or epiretinal membrane
• Subjects who may need or have received systemic anti-VEGF for oncology in the past year
• Subjects with history of anti-VEGF injection within 4 months before vitrectomy

Where it is running

• California Retina Consultants - Santa Barbara Office — Santa Barbara, California, United States (enrolling)

Full record on ClinicalTrials.gov

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