A Study to Evaluate the Efficacy and Safety of Erenumab (AMG 334) in Chronic Migraine Prevention

Completed · Phase 2 · Has a placebo group

Conditions studied: Treatment for Prevention of Chronic Migraine

In brief

To evaluate the effect of erenumab compared to placebo on the change from baseline in the number of monthly migraine days in adults with chronic migraine.

Key facts

Study ID

NCT02066415

Run by

Amgen

People needed

667

Starts

2014-03-05

Expected to finish

2016-04-28

Last updated by the study team

2022-10-12

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• History of at least 5 attacks of migraine without aura and/or migraine with visual sensory, speech and/or language, retinal or brainstem aura.
• History of ≥ 15 headache days per month of which ≥ 8 headache days were assessed by the subject as migraine day.
• ≥ 4 distinct headache episodes, each lasting ≥ 4 hours OR if shorter, associated with use of a triptan or ergot-derivative on the same calendar day based on the eDiary calculations.
• Demonstrated at least 80% compliance with the eDiary.

You may not qualify if…

• History of cluster headache or hemiplegic migraine headache
• Unable to differentiate migraine from other headaches
• Failed > 3 medication categories due to lack of efficacy for prophylactic treatment of migraine .
• Received botulinum toxinin head or neck region within 4 months prior to screening.
• Used a prohibited migraine prophylactic medication, device or procedure within 2 months prior to the start of the baseline phase

Where it is running

• Research Site — Newport Beach, California, United States
• Research Site — San Francisco, California, United States
• Research Site — Santa Monica, California, United States
• Research Site — Sherman Oaks, California, United States
• Research Site — Stanford, California, United States
• Research Site — Stamford, Connecticut, United States
• Research Site — Jacksonville, Florida, United States
• Research Site — Orlando, Florida, United States
• Research Site — Palm Beach Gardens, Florida, United States
• Research Site — West Palm Beach, Florida, United States
• Research Site — Atlanta, Georgia, United States
• Research Site — Decatur, Georgia, United States
• Research Site — Indianapolis, Indiana, United States
• Research Site — Pikesville, Maryland, United States
• Research Site — Watertown, Massachusetts, United States
• Research Site — Worcester, Massachusetts, United States
• Research Site — Ann Arbor, Michigan, United States
• Research Site — Kalamazoo, Michigan, United States
• Research Site — Springfield, Missouri, United States
• Research Site — St Louis, Missouri, United States
• Research Site — Reno, Nevada, United States
• Research Site — Amherst, New York, United States
• Research Site — Greensboro, North Carolina, United States
• Research Site — Cleveland, Ohio, United States
• Research Site — La Jolla, California, United States

Full record on ClinicalTrials.gov

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