High Omega-3/Low Omega-6 Treatment Diet for Aspirin-exacerbated Respiratory Disease (AERD)

Completed · Not applicable

Conditions studied: ASA Triad, Asthma, Nasal Polyps, And Aspirin Intolerance

In brief

The purpose of this trial is to test the hypothesis that a treatment diet low in omega-6 fatty acids and high in omega-3 fatty acids can cause improvement in asthma symptoms, nasal symptoms, and pulmonary function in patients with aspirin-exacerbated respiratory disease (AERD).

Key facts

Study ID: NCT02064738
Run by: Brigham and Women's Hospital
People needed: 10
Starts: 2014-03-01
Expected to finish: 2017-04-01
Last updated by the study team: 2019-01-16

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

History of physician-diagnosed asthma
History of nasal polyposis
History of at least two reactions to oral aspirin or other nonselective cyclooxygenase inhibitor with features of lower airway involvement (cough, chest tightness, wheezing, dyspnea), or diagnosis of AERD via a physician-conducted challenge to aspirin
Age between 18 and 70 years

You may not qualify if…

Current smoking, defined as daily tobacco smoking in the last 6 months and at least one instance of tobacco smoking in the last 3 months.
Current pregnancy or breastfeeding
BMI <20
History of allergy to fish or any unwillingness to eat fish as a regular part of the diet
Use of Zyflo (zileuton) in the last two weeks
Presence of an implantable cardioverter-defibrillator
Use of oral steroids in the last two weeks
Participation in any other clinical trial in the last month
Any use of nonsteroidal antiinflammatory drugs (NSAIDs) or any drug that inhibits the cyclooxygenase enzyme during the course of the study

Where it is running

Brigham and Women's Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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