Physical Activity and Obesity

Completed · Not applicable

Conditions studied: Obesity, Prediabetic State, Sedentary Lifestyle

In brief

The purpose of the study is to see if a twelve-week exercise intervention in overweight or obese subjects with pre-diabetes or early disease course type 2 diabetes can lead to improved skeletal muscle capillary blood flow by improving substances that dilate blood vessels and result in improved insulin sensitivity.

Key facts

Study ID

NCT02060240

Run by

Oregon Health and Science University

People needed

30

Starts

2014-02-01

Expected to finish

2017-04-01

Last updated by the study team

2019-08-06

Who can join

Age: 30 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males and females ages 30-60 years of age
• Overweight and Obese (28< BMI <45)
• Confirmed pre-diabetic (5.7≤ HbA1c < 6.5)
• Type 2 DM, Diagnosis 2 years or less, on no medications or metformin only, HbA1c ≤ 6.7

You may not qualify if…

• Stage 3 chronic kidney disease (glomerular filtration rate [GFR] < 60)
• Obstructive Coronary artery disease
• Congestive heart failure (ejection fraction < 55%)
• Peripheral vascular disease,
• Degenerative joint disease, musculoskeletal disease, or peripheral vascular disease that limits ability to exercise
• Know hypersensitivity to Definity® ultrasound contrast agent
• Intra-cardiac or pulmonary shunt
• The use of antithrombotic agents or a severe bleeding diathesis due to risk of bleeding with intravenous and arterial line placement
• Physical activity greater than three hours per week
• Pregnancy

Where it is running

• Oregon Health & Science University — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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