Developing Effective Response Inhibition Training for Symptom Relief in OCD and Trichotillomania

Completed · Not applicable · Has a placebo group

Conditions studied: Obsessive Compulsive Disorder, Trichotillomania

In brief

Obsessive-compulsive disorder (OCD) and its related disorders (e.g., trichotillomania) are characterized by the marked difficulty in inhibiting unwanted or inappropriate responses. There is compelling evidence that poor response inhibition is a core cognitive feature of OCD and its related disorders, but no effective intervention exists that directly attempts to address this problematic cognitive deficiency. This study will examine the feasibility and clinical utility of a computerized cognitive training program designed to improve response inhibition among individuals diagnosed with OCD or trichotillomania.This training program offers systematic practice of response inhibition in the form of a 40-level computer game. Individuals with these conditions will be randomized to either 8 sessions of (a) computerized response inhibition training (RIT) or (b) placebo computer training (PLT). We hypothesize that RIT will outperform PLT in improving response inhibition capabilities and reducing relevant clinical symptoms. In sum, this project is expected to generate important knowledge to guide the development of effective computer-based treatment approaches that may help reduce critical problems of existing treatments such as suboptimal patient retention and treatment under-utilization, thereby improving overall treatment response rates among individuals suffering from OCD and related conditions.

Key facts

Study ID

NCT02059980

Run by

University of Wisconsin, Milwaukee

People needed

45

Starts

2014-08-01

Expected to finish

2017-08-01

Last updated by the study team

2018-09-26

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Principal diagnosis of obsessive-compulsive disorder or trichotillomania

You may not qualify if…

• Current substance use problems
• Current/Past Psychotic disorder, bipolar disorder, or schizophrenia
• Attention deficit/hyperactivity disorder or tic disorder
• Severe depressive symptoms
• Current psychotherapy
• Current suicidality
• Estimated intellectual functioning < 80
• Lack of response inhibition deficits on a stop-signal task

Where it is running

• Psychology Clinic, University of Wisconsin-Milwaukee — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

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