The Effect of Surfactants on the Bacterial Composition of the Layers of the Skin

Withdrawn before enrolling · Not applicable

Conditions studied: Focus: Healthy Skin Microbiome

In brief

Recent research in the investigator's lab has shown that bacteria are present not only on the outer surface of our skin, but also in the deeper components as well. In this study, the investigator will study the bacteria present in different components of the skin including the epidermis, dermis, subcutaneous fat, and hair follicle, and determine if and how these bacteria change after repeated use of different commercially available hand soaps. It is expected that the bacteria populations in the different skin components will change with the use of different soaps.

Key facts

Study ID

NCT02057055

Run by

University of California, San Diego

People needed

0

Starts

2014-02-01

Expected to finish

2016-08-01

Last updated by the study team

2018-08-22

Who can join

Age: 21 and older, up to 35. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Age 21-35 years
• Male subject of any race and ethnicity
• Subject agrees to comply with study requirements

You may not qualify if…

• Subjects with severe medical condition(s) that in the view of the investigator prohibits participation in the study
• Dermatologic disease such as psoriasis or atopic dermatitis which may have inherently abnormal antimicrobial peptide levels
• Subject has Netherton's syndrome or other genodermatoses that result in a defective epidermal barrier
• Pregnant or nursing females
• Immunocompromised subjects (e.g., lymphoma, HIV/AIDS, Wiskott-Aldrich Syndrome), or with a history of active or malignant disease (excluding non-melanoma skin cancer) as determined by the participant's medical history.
• Subjects with a history of psychiatric disease or history of alcohol or drug abuse that would interfere with the ability to comply with the study protocol
• Active viral or fungal skin infections at the target areas
• Are currently receiving lithium, antimalarials, or intramuscular gold now or within the last 4 weeks.
• Ongoing participation in an investigational drug trial
• Use of any oral or topical antibiotic during the study and up to one week prior to entering the study
• Use of any local topical medications less than one week prior to screening
• Use of any systemic immunosuppressive therapy less than four weeks prior to screening.
• Subjects with a history of or propensity to developing reactions after use of over the counter cleansers
• Subjects with diabetes
• Injured, broken skin
• Allergy to local anesthetic medications, including lidocaine

Where it is running

• University of California San Diego Division of Dermatology — San Diego, California, United States

Full record on ClinicalTrials.gov

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