FLT-PET/MRI for Early Response Monitoring to Novel Cancer Therapeutic Agents
Completed
Conditions studied: Unspecified Adult Solid Tumor, Protocol Specific
In brief
This pilot clinical trial studies fluorine F 18 fluorothymidine (FLT)-positron emission tomography/magnetic resonance imaging (PET/MRI) in measuring early response in patients with metastatic solid tumors receiving treatment that blocks blood flow to the tumor. Diagnostic procedures, such as FLT-PET/MRI, may help measure a patient's response earlier during treatment.
Key facts
- Study ID
- NCT02055586
- Run by
- Case Comprehensive Cancer Center
- People needed
- 10
- Starts
- 2013-10-22
- Expected to finish
- 2017-12-27
- Last updated by the study team
- 2020-09-18
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with metastatic solid tumors scheduled to undergo treatment with novel cancer therapeutic agents as standard of care (SOC) treatment.
- Patients able to tolerate PET/MRI scans
- Informed consent must be given and signed
You may not qualify if…
- Subjects who do not meet the above mentioned inclusion criteria
- Subjects who refuse to give and/or sign the informed consent
- Patients who currently have a pacemaker
- Patients who have a history of serious adverse events related to a previous MRI or PET/CT
- Patients who are unable to undergo MRI scanning due to exclusion by UHCMC MRI restriction policies as mentioned in the standard UHCMC MRI informed consent form
- Patients with a known allergy against any component of the contrast enhancing agent
- Patients who currently pregnant or breast feeding; negative serum pregnancy test within 72 hours of their first FLT-PET/MRI
- Anti-cancer treatment (chemotherapy and/or radiation therapy) within the last 4 weeks
- Renal insufficiency: elevated creatinine and/or glomerular filtration rate (GFR) < 40 ml/min/1.73\^2 (exclusion criterion only for contrast enhanced MRI)
Where it is running
- Case Comprehensive Cancer Center — Cleveland, Ohio, United States
Full record on ClinicalTrials.gov
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