Association Between Haptoglobin Genotype and Brain Swelling
Stopped early
Conditions studied: Intracerebral Hemorrhage
In brief
Intracerebral hemorrhage is bleeding into the brain and is a major cause of stroke and other complications. Brain injury from intracerebral hemorrhage occurs in two phases. The early phase involves the mechanical compression of brain tissue by the expanding hematoma. In a later phase, brain swelling develops causing further compression that may lead to brain herniation and death. This study investigates the neuroprotective role of haptoglobin, in minimizing the development of brain swelling following intracerebral hemorrhage.
Key facts
- Study ID
- NCT02054117
- Run by
- University of Florida
- People needed
- 9
- Starts
- 2014-03-01
- Expected to finish
- 2015-03-01
- Last updated by the study team
- 2015-03-05
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Spontaneous intracranial or intraparenchymal hemorrhage
- 18-85 years of age
- Hemorrhage occurred in a supratentorial location
You may not qualify if…
- Inability to obtain consent within 3 days of hemorrhage onset
- Known pregnancy
- Therapeutic anticoagulation with Lovenox, Coumadin or Heparin
- Prior history of therapeutic radiation to any area
- Brain tumor
- Hemorrhage related to trauma, aneurysm, arteriovenous malformation or other vascular malformation
- Central nervous system infection
- Subdural hematoma
- Subarachnoid hemorrhage
- Chronic immunosuppression, including steroids or chemotherapy agents
- Infratentorial location
- Unable to obtain MRI due to mental status or other contraindication (metal, pacemaker, etc.)
Where it is running
- University of Florida — Gainesville, Florida, United States
Full record on ClinicalTrials.gov
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