The Effects of Modified Ultrafiltration on Vancomycin Levels During Cardiopulmonary Bypass in Cardiac Surgery
Completed · Early Phase 1
Conditions studied: Infection
In brief
Antibiotics are routinely used to prevent surgical wound infection. Vancomycin is a widely used antibiotic for surgery in patients with an allergy to penicillin. During cardiac surgery, cardiopulmonary bypass (CPB) and modified ultrafiltration (MUF) are routinely used and can lower the level of the antibiotic. The purpose of this study is to quantify the change in plasma vancomycin concentration associated with cardiopulmonary bypass and modified ultrafiltration.
Key facts
- Study ID
- NCT02051595
- Run by
- University of Florida
- People needed
- 25
- Starts
- 2014-04-01
- Expected to finish
- 2015-04-01
- Last updated by the study team
- 2019-08-13
Who can join
Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Scheduled to undergo cardiac surgery with cardiopulmonary bypass and modified ultrafiltration
- age greater than 18 years old
- penicillin allergy or in-hospital stay greater than 24 hours
- normal renal function
- normal liver function
- absence of clinical and laboratory signs of infection
You may not qualify if…
- vancomycin allergy
- pregnancy
- impaired renal function
- impaired liver function
- morbid obesity
- active infections
- Jehovah's Witness
Where it is running
- UF Health — Gainesville, Florida, United States
Full record on ClinicalTrials.gov
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