The TIME-2 Study: A Phase 2 Study of AKB-9778, a Novel Tie-2 Activator, in Patients With Diabetic Macular Edema

Completed · Phase 2 · Has a placebo group

Conditions studied: Diabetic Macular Edema (DME)

In brief

The purpose of this study is to evaluate the safety and efficacy of AKB-9778 administered as daily subcutaneous injections with and without monthly intravitreal injections of ranibizumab for 3 months in patients with diabetic macular edema.

Key facts

Study ID

NCT02050828

Run by

Aerpio Therapeutics

People needed

144

Starts

2014-01-01

Expected to finish

2015-05-01

Last updated by the study team

2017-03-16

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Study site — Pheonix, Arizona, United States
• Study site — Pheonix, Arizona, United States
• Study site — Tucson, Arizona, United States
• Study site — Arcadia, California, United States
• Study site — Bakersfield, California, United States
• Study site — Beverly Hills, California, United States
• Study site — Palm Desert, California, United States
• Study site — Sacramento, California, United States
• Study site — Santa Ana, California, United States
• Study site — Santa Barbara, California, United States
• Study site — Golden, Colorado, United States
• Study site — Boynton Beach, Florida, United States
• Study site — Fort Lauderdale, Florida, United States
• Study site — Fort Myers, Florida, United States
• Study site — Miami, Florida, United States
• Study site — Sarasota, Florida, United States
• Study site — Stuart, Florida, United States
• Study site — Winter Haven, Florida, United States
• Study site — Baltimore, Maryland, United States
• Study site — Jackson, Michigan, United States
• Study site — Omaha, Nebraska, United States
• Study site — Reno, Nevada, United States
• Study site — Rochester, New York, United States
• Study site — Charlotte, North Carolina, United States
• Study site — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

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