Changes in Gut Hormones, Body Composition and Energy Expenditure After Roux-en-Y
Completed · Not applicable
Conditions studied: Obesity, Weight Loss
In brief
The purpose of this study is to gain a better understanding of the mechanism of weight regain through gut hormone (substances in the gut that control various functions of the digestive organs) and energy expenditure (the amount of energy a person uses to complete bodily activities). Our hypothesis is that gut hormone response might be different among subjects who are able to maintain weight loss and subjects with weight regain. For this study, investigators will measure fasting and postprandial (happening after a meal) gut hormones, bile acid, amino acids, vitamin B, vitamin D, myokines and adipokine levels in obese individuals who are at least 2 years after a Roux-en-Y gastric bypass (RYGB). Investigators will also measure resting metabolic rate (RMR) (the amount of energy expended daily) and body composition (the proportion of fat, muscle, and bone of an individual's body). The subjects body composition will be analyzed, including fat mass and fat free mass, by a Dual-Energy X-ray Absorptiometry (DEXA). This study will provide more information regarding the effect of RYGB on gut hormones, adipokines, bile acids, amino acids, and energy expenditure and body compositions.
Key facts
- Study ID
- NCT02048501
- Run by
- Duke University
- People needed
- 57
- Starts
- 2014-01-01
- Expected to finish
- 2015-03-01
- Last updated by the study team
- 2017-04-26
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age between 18-65 years of age
- Ability and willingness to provide informed consent
You may not qualify if…
- Surgical/anatomical failure such as pouch enlargement, anastomosis dilation, formation of a gastrogastric fistula,
- Currently on medication that might affect weight gain including GLP-1 analog
- Inability to provide informed written consent.
- Any known history of abnormal thyroid function.
- Females who are pregnant.
Where it is running
- Duke Center for Metabolic and Weight Loss Surgery — Durham, North Carolina, United States
Full record on ClinicalTrials.gov
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