Airway Inflammatory Response During Illness in Children With Respiratory Failure
Withdrawn before enrolling
Conditions studied: Acute Respiratory Failure, Acute Respiratory Infection, Acute Respiratory Distress Syndrome
In brief
The purpose of this study has two major goals: 1) to measure the amount of two specific hormones interleukin (IL)-10 and interleukin (IL)-12p70 in mucous and blood; and 2) compare the hormone levels in two specific areas of the lung called the trachea (upper airway) and the bronchioles (lower airway). The hormones IL-10 and IL-12p70 are cytokines, special hormones cells use to communicate with each other during inflammation or infection. Cytokines can be measured in mucous and blood. The balance of one cytokine compared to another help doctors to understand how people respond differently to infection. Unfortunately, the amount of IL-10 and IL-12p70 is not known in children, especially children with a lung infection. In addition, we do not know if the balance of these cytokines differ in various regions of the lung. We believe the balance of IL-10 and IL-12p70 is similar whether measured in the upper or lower airways.
Key facts
- Study ID
- NCT02047877
- Run by
- University of North Carolina, Chapel Hill
- People needed
- 0
- Starts
- 2017-07-01
- Expected to finish
- 2019-08-01
- Last updated by the study team
- 2017-11-14
Who can join
Age: any, up to 17. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Previously healthy
- Age 37 weeks gestation through 17 years
- Presumed respiratory infection
- Intubated <48 hours
You may not qualify if…
- Trauma, Drowning, Pancreatitis, or Sepsis not originating from a pulmonary infection.
- Pre-existing chronic disease including:
- congenital heart disease or acquired cardiomyopathy
- pulmonary hypertension
- restrictive lung disease
- cystic fibrosis
- asthma controlled with chronically inhaled steroids
- Tracheostomy
- Immunocompromised including chronic steroid use within last month
- Oncological condition except conditions in active remission not requiring maintenance chemotherapy.
- Intubated patient with an endotracheal tube <3.5 mm
- Patients with persistent SpO2 <90% despite adequate ventilator support, or patients deemed too unstable to undergo mini-BAL by the clinical care team
Where it is running
- University of North Carolina Hospital at Chapel Hill — Chapel Hill, North Carolina, United States
Full record on ClinicalTrials.gov
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