The Effects of Exercise on Appetite Regulation in Overweight/Obese Individuals
Completed · Not applicable
Conditions studied: Obesity
In brief
In this study the Investigators are examining the effects of a 12-week exercise program (intervention) on measures of appetite and food intake regulation in overweight to mildly obese healthy adults. The Investigators hypothesize that individuals who lose a significant amount of weight in response to the intervention will show a reduction in the brain response to food cues as measured by functional magnetic resonance imaging (fMRI) when compared to those who do not lose weight. These changes in neuronal activity will be associated to physiologic and behavioral measures.
Key facts
- Study ID
- NCT02047721
- Run by
- University of Colorado, Denver
- People needed
- 69
- Starts
- 2014-02-01
- Expected to finish
- 2019-06-19
- Last updated by the study team
- 2020-10-22
Who can join
Age: 21 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- all ethnic groups and both genders;
- age: 21-45 yrs;
- BMI: 27-35;
- weight stable within +/- 5 percent in the last 6 months;
- sedentary (less than 1 hour of planned physical activity by self-report).
You may not qualify if…
- history of cardiovascular disease (CVD), diabetes mellitus, uncontrolled hypertension, untreated thyroid disease, renal disease, hepatic disease, or any other medical condition affecting weight or energy metabolism;
- unable to effectively exercise due to cardiac, pulmonary, neurologic or orthopedic reasons;
- unable to pass screening graded exercise treadmill test;
- currently smoking;
- medications affecting weight, Energy Intake (EI) or Energy Expenditure (EE) in the last 6 months;
- weight loss or weight gain of >5 percent in past 6 months;
- currently pregnant, lactating or less than 6 months post-partum;
- bariatric surgery;
- major psychiatric disorder, presence of alcohol or substance abuse, current depression by history and/or a score >21 on the he Center for Epidemiologic Studies Depression Scale (CES-D), history of eating disorders and/or a score of >20 on the EATS-26;
- contraindication to MRI
Where it is running
- Univeristy of Colorado — Aurora, Colorado, United States
Full record on ClinicalTrials.gov
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