Randomized Controlled Trial of Aspirin vs Placebo in the Treatment of Pre-psychosis

Stopped early · Early Phase 1 · Has a placebo group

Conditions studied: Clinical High Risk for Psychosis

In brief

The primary objective of this study is to determine whether aspirin is effective in alleviating symptoms of the clinical high risk (CHR) syndrome for psychosis. The investigators further aim to determine whether it may delay or prevent the onset of psychosis in those currently experiencing CHR symptoms. As secondary measures the investigators aim to collect laboratory studies of inflammation markers and genetic samples to determine whether certain genetic profiles correlate with risk for psychosis, or response to aspirin treatment.

Key facts

Study ID

NCT02047539

Run by

Yale University

People needed

1

Starts

2015-01-01

Expected to finish

2021-03-01

Last updated by the study team

2021-05-17

Who can join

Age: 19 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 19 - 35
• Must have a SIPS interview
• CHR subjects must meet at least one of 3 CHR syndromes defined by SIPS
• Must demonstrate adequate decisional capacity

You may not qualify if…

• Under age of 19
• Have pre-existing gastrointestinal disease, heart disease
• Have kidney disease
• Taking non-steroidal anti-inflammatory medications
• Hypersensitive to NSAID (non-steroidal anti-inflammatory medications)
• Have coexisting unstable major medical illness
• Are pregnant or breastfeeding
• Consume more than 2 drinks of alcohol per day
• Have a blood clotting disorder
• Are taking ACE inhibitors, acetazolamide, anticoagulants, anticonvulsants, beta blockers, diuretics, methotrexate, oral hypoglycemic or uricosuric agents
• Have a history of substance abuse in past three moths or dependence in past 6 months

Where it is running

• PRIME Research Clinic — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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