Brain Biomarkers of Response to Treatment for Apraxia of Speech

Completed · Not applicable

Conditions studied: Aphasia, Stroke

In brief

The study will use MRI brain imaging to identify brain changes associated in stroke patients after they receive speech-language treatment for their speech difficulties.

Key facts

Study ID

NCT02046941

Run by

VA Office of Research and Development

People needed

17

Starts

2014-03-01

Expected to finish

2018-06-30

Last updated by the study team

2019-08-28

Who can join

Age: 40 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Inclusion criteria are age 40-90
• primary English speaker since < age 5
• a history of a single left hemisphere stroke
• at least 1 year post-stroke
• at least 12 years of education
• pre-morbidly right-handed (Edinburgh Handedness Questionnaire)
• within normal limits on the Test of Non-Verbal Intelligence

You may not qualify if…

• Exclusion criteria will include a pre-morbid neurologic or psychiatric history
• history/current substance abuse disorder
• MRI contraindications
• other motor speech disorders (e.g., dysarthria)
• current or recent (<2 months) speech/language therapy
• prior SPT
• pre-morbid history of speech/language disorders
• significant hearing disabilities (based on a pure-tone audiological screen at 35 dB HL at 500, 1K, and 2K Hz for at least one ear)
• aphasia severity resulting in <30th percentile performance on the Porch Index of Communicative Ability-R

Where it is running

• VA Northern California Health Care System, Mather, CA — Sacramento, California, United States

Full record on ClinicalTrials.gov

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