Neuroimaging of Dystonia

Completed

Conditions studied: Primary Cervical Dystonia, DYT 1 Dystonia

In brief

The main purpose of this study is to investigate primary cervical dystonia as compared to healthy control subjects and DYT 1 dystonia as compared to healthy control subjects by examining cognitive measures, physical measures, and structural and functional magnetic resonance imaging (MRI). The secondary aim of this study is to investigate a specific drug therapy for primary cervical dystonia to develop a functional MRI (fMRI) research paradigm. The drug, trihexyphenidyl, is FDA approved to treat Parkinson's Disease and is commonly prescribed by physicians as a treatment for symptoms of primary cervical dystonia.

Key facts

Study ID

NCT02046447

Run by

University of Florida

People needed

20

Starts

2014-05-01

Expected to finish

2017-12-01

Last updated by the study team

2017-12-22

Who can join

Age: 7 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Diagnosis of primary cervical dystonia and between the ages of 18-70, OR
• Diagnosis of DYT 1 dystonia and between the ages of 7-50, OR
• Healthy control and between the ages of 7-70

You may not qualify if…

• Neurological impairment from: seizure disorders, stroke, hypertension, heart disease, diabetes, traumatic brain injury (TBI), drug abuse, nerve disorders, dementia, Parkinson's Disease, dementia
• Not a candidate for magnetic resonance imaging (MRI)
• Deep brain stimulation (DBS) surgery
• Any implanted electrical device
• Pregnant or planning pregnancy
• Breastfeeding
• Claustrophobia

Where it is running

• University of Florida — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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