RCT (Randomized Controlled Trial) of IV Acetaminophen for Post Cesarean Pain Relief

Completed · Phase 4 · Has a placebo group

Conditions studied: Cesarean Section, Pain, Postoperative

In brief

This study is being done to evaluate the scheduled use of intravenous (IV) acetaminophen among cesarean section patients. The study hopes to find out if patients who receive scheduled IV acetaminophen for 48 hours following delivery have lower self-reported pain scores and use less narcotic pain medication than patients who do not receive IV acetaminophen.

Key facts

Study ID

NCT02046382

Run by

TriHealth Inc.

People needed

132

Starts

2014-01-01

Expected to finish

2017-05-01

Last updated by the study team

2018-08-16

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Age greater than or equal to 18 years
• Scheduled cesarean section delivery
• Patient of TriHealth's Faculty Medical Center or Tri-State Maternal Fetal Medicine Associates
• Singleton pregnancy
• Term delivery (greater than or equal to 37 weeks)
• Spinal/epidural anesthesia with epidural analgesia (duramorph)
• Use of pfannenstiel incision

You may not qualify if…

• Weight less than 50 kg
• Allergy to study drugs (acetaminophen, oxycodone, duramorph, NSAIDS)
• Multiple gestation pregnancy
• Cesarean section for pre-term delivery (less than 37 weeks)
• Fetal anomalies
• Inability to use epidural duramorph at time of procedure
• General anesthesia used
• Vertical skin incision
• Opioid addiction
• Liver dysfunction (hepatitis, HELLP (hemolysis, elevated liver enzymes, and low platelet count), preeclampsia)

Where it is running

• TriHealth Good Samaritan Hospital — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

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