MR Imaging Biomarkers of Disease Response to ECT (Electroconvulsive Therapy) in Depression
Completed
Conditions studied: Depression
In brief
The purpose of this study is to (a) measure how brain structure, metabolism (how the brain uses energy), and function predict response to electroconvulsive therapy (ECT) for treatment of depression; and (b) measure how ECT changes brain metabolism and function. We will ask you to undergo magnetic resonance imaging (MRI) at three sessions: (1) prior to your first ECT therapy session, (2) after having 4-6 ECT therapy sessions, and (3) approximately two months following your first ECT therapy sessions.
Key facts
- Study ID
- NCT02044289
- Run by
- University of Arkansas
- People needed
- 12
- Starts
- 2014-06-01
- Expected to finish
- 2015-12-01
- Last updated by the study team
- 2016-02-03
Who can join
Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Men and women ages 18 and older
- Diagnosis of major depressive disorder based on the SCID
- Score of 20 or more on the HAM-D at enrollment
- Ability to provide informed consent
- Referral for ECT, clinical assessment (health screening, i.e. "work-up") confirming suitability of receiving ECT, and consent to receive ECT
- Ability to speak English (necessary for SCID) and an 8th grade English reading equivalency (necessary for completing assessment forms)
You may not qualify if…
- Claustrophobia, or the inability to lie still in a confined space
- Magnetic metallic implants (such as screws, pins, shrapnel remnants, aneurysm clips, artificial heart valves, inner ear (cochlear) implants, artificial joints, and vascular stents), as these may heat, pull, or twist in the strong magnetic field of the MRI scanner
- Electronic or magnetic implants, such as pacemakers, as these may stop working
- Non-removable dental implants, such as braces or permanent retainers, as these will distort the MRI images we collect (note: filings, crowns, and silver or gold teeth are OK)
- Permanent makeup or tattoos with metallic dyes
- Self-report of pregnancy at intake
- A positive pregnancy test (for females), since the effect of strong magnetic fields on the developing fetus remains unknown and inconclusive. (We will conduct a pregnancy test for all female participants on the day of the MRI scan.)
- A self-reported history of loss of consciousness (greater than 10 minutes)
- Physical disabilities that prohibit task performance (such as blindness or deafness)
- Any other condition that the investigator believes might put the participant at risk
Where it is running
- University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
Full record on ClinicalTrials.gov
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