Retinal Oxygen Function After Radiation Therapy

Completed

Conditions studied: A History of Radiation Therapy for a Tumor in the Vicinity of the Retina(s)

In brief

The investigators propose using retinal oximetry to assess for abnormalities in regional retinal oxygen consumption in previously- irradiated patients, and relate these abnormalities to changes in regional retinal function (i.e. visual field abnormalities). Since different regions of retina receive different radiation doses, the investigators will assess for a dose response as well.

Key facts

Study ID

NCT02043470

Run by

UNC Lineberger Comprehensive Cancer Center

People needed

32

Starts

2011-03-01

Expected to finish

2017-05-04

Last updated by the study team

2019-08-28

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ≥ 18 years of age at the time of radiation therapy (no upper age limit)
• History of radiation therapy delivered at UNC-CH or Rex Hospital to the vicinity of the retina(s) ≥ 2 months prior to enrollment
• Estimated average dose to at least one quadrant of one retina ≥ 30 Gy

You may not qualify if…

• History of diabetes, retinal vascular occlusions, glaucoma, retinitis pigmentosa, occipital stroke or any other ophthalmologic or systemic problem that may confound visual field results.
• Residual tumor within the visual pathway: retina, optic nerves, optic chiasm, optic radiations and brain.

Where it is running

• Department of Radiation Oncology Clinic — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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