Pilot Study of Multi-Modality Imaging in Patients With Hematologic Malignancies
Stopped early · Not applicable
Conditions studied: Hematologic Malignancy
In brief
This is a pilot sub-study of patients receiving myeloablative transplant using total body irradiation (TBI) or total marrow irradiation (TMI) in their preparative regimen. The objective of this stub-study is to estimate the heterogeneity in cellular proliferation (FLT-PET uptake) as well the heterogeneity in marrow composition distribution (measured using whole body water-fat MRI) using positron emission tomography imaging. This will be used to design future trials as well as to determine the feasibility of PET and MRI imaging.
Key facts
- Study ID
- NCT02042924
- Run by
- Masonic Cancer Center, University of Minnesota
- People needed
- 2
- Starts
- 2014-01-01
- Expected to finish
- 2015-11-01
- Last updated by the study team
- 2017-12-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of hematologic malignancy and fitting into one of the following categories:
- Newly diagnosed and/or day 14 post-induction chemotherapy
- Relapsed, including relapse after hematopoietic cell transplant
- Planned hematopoietic cell transplant (if enrolling at "close") or within 100 days post hematopoietic cell transplant (if enrolling post-transplant) with a preparative regimen that includes either total marrow irradiation (TMI) or total body irradiation (TBI)
- Undergoing natural killer cell therapies (with or without subsequent transplant)
- Aged 18 years and older
- Not pregnant - women of childbearing potential will have a confirmatory pregnancy test prior to each imaging per routine procedures
- Adequate renal function (estimated glomerular filtration rate > 60 ml/min) as determined by a serum creatinine level performed as a part of standard of care within 7 days of imaging
- Able and willing to provide written consent
You may not qualify if…
- Otherwise eligible patients meeting one or more of the contraindicates for an MRI, may enroll in the study without undergoing the MRI:
- ferromagnetic implants
- history of shrapnel or shot gun injury
- too large to fit in the magnet (approximate body mass index ≥ 40)
- cardiac pacemakers or other implanted devices that are not MR-compatible
- claustrophobia
- large tattoos
Where it is running
- University of Minnesota Masonic Cancer Center — Minneapolis, Minnesota, United States
Full record on ClinicalTrials.gov
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