Transfusion Requirements in Cardiac Surgery III

Completed · Not applicable

Conditions studied: Disorder; Heart, Functional, Postoperative, Cardiac Surgery

In brief

TRICS-III is an international, multi-centre, open-label randomized controlled trial of two commonly used transfusion strategies in high risk patients having cardiac surgery using a non-inferiority trial design.

Key facts

Study ID

NCT02042898

Run by

Unity Health Toronto

People needed

5028

Starts

2014-01-20

Expected to finish

2017-10-01

Last updated by the study team

2018-08-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 or older
• Planned cardiac surgery using cardiopulmonary bypass
• Informed consent obtained
• Preoperative European System for Cardiac Operative Risk Evaluation (EuroSCORE I) of 6 or more

You may not qualify if…

• Patients who are unable to receive or who refuse blood products
• Patients who are involved in a preoperative autologous pre-donation program
• Patients who are having a heart transplant or having surgery solely for an insertion of a ventricular assist device
• Pregnancy or lactation (a negative pregnancy test must be obtained prior to randomization for women of childbearing potential.)
• Patients who are unable to receive or who refuse blood products

Where it is running

• Yale-New Haven Hospital — New Haven, Connecticut, United States
• Maine Medical Center — Portland, Maine, United States
• Montefiore Medical Center — The Bronx, New York, United States
• Durham Veterans Affairs Medical Center — Durham, North Carolina, United States
• University of Texas Southwestern Medical Center — Dallas, Texas, United States
• Baylor College of Medicine — Houston, Texas, United States
• Michael E. DeBakey Veterans Affairs Medical Center — Houston, Texas, United States
• Royal Prince Alfred Hospital — Camperdown, New South Wales, Australia
• Royal North Shore Hospital — Sydney, New South Wales, Australia
• Westmead Hospital — Westmead, New South Wales, Australia
• Royal Adelaide Hospital — Adelaide, South Australia, Australia
• Flinders Medical Centre — Bedford Park, South Australia, Australia
• Monash Medical Centre — Clayton, Victoria, Australia
• St Vincent's Hospital, Melbourne — Fitzroy, Victoria, Australia
• Austin Hospital — Heidelberg, Victoria, Australia
• Cabrini Health — Malvern, Victoria, Australia
• Alfred Hospital — Melbourne, Victoria, Australia
• Barwon Health (University Hospital Geelong) — Melbourne, Victoria, Australia
• Royal Melbourne Hospital — Parkville, Victoria, Australia
• Hospital Unimed Rio (National Institute of Cardiology) — Rio de Janeiro, Brazil
• Foothills Medical Centre — Calgary, Alberta, Canada
• University of Alberta — Edmonton, Alberta, Canada
• Kelowna General Hospital — Kelowna, British Columbia, Canada
• Vancouver General Hospital — Vancouver, British Columbia, Canada
• San Francisco VA Medical Center — San Francisco, California, United States

Full record on ClinicalTrials.gov

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