Mediators of Kidney-Bone Communication in Childhood
Completed
Conditions studied: Fasting Blood Measures, Body Scans
In brief
An identified hormone linking bone and kidney function is Fibroblast Growth Factor-23 (FGF23). Data on the variation of FGF23 levels for bone and mineral metabolism in children are scarce. Currently it is assumed that meeting mineral requirements for the skeleton serves the body's overall needs. However, it is not clear as to whether this is true, particularly with growth. The contribution of dietary factors directly linked with the bone/kidney axis through measurement of intake (via 24hr recall) and kidney nutrient clearance (via serum and urinary analysis) will be included in investigations. Findings will serve as a springboard for delineating more specific mechanisms by which these systems become disordered and are influenced by diet. It is expected that adequacy of nutrients known to have a central role in bone function will optimize the hormonal milieu through crosstalk with the kidney. This effort will allow ongoing investigation in detecting and treating disturbances in mineral metabolism related to kidney disease, specifically in the pediatric population and broaden the understanding of kidney disease itself, as well as that of chronic diseases in which kidney health is of importance, such as diabetes and osteoporosis. Findings of this research may stress the importance of achieving dietary adequacy essential for establishing optimal body composition trajectories, particularly puberty.
Key facts
- Study ID
- NCT02040740
- Run by
- University of Alabama at Birmingham
- People needed
- 26
- Starts
- 2013-03-01
- Expected to finish
- 2013-06-01
- Last updated by the study team
- 2019-11-25
Who can join
Age: 7 and older, up to 12. Sex: male. Healthy volunteers: accepted.
You may qualify if…
- Male
- ages 7-11y
- Tanner stage less than or equal to 3 according to the criteria of Marshall and Tanner
You may not qualify if…
- History of Cushing's Syndrome, hyperprolactinemia, congenital (non-classic) adrenal hyperplasia, type 1 or 2 diabetes, disturbances in glucose or lipid metabolism
- use of tobacco or consumption of alcohol; thyroid medication, diuretics, beta-blockers, or any medication that potentially could affect body composition, the lipid profile, insulin sensitivity, or blood pressure
- eating disorders, cancer, kidney disease, endocrinopathy, liver disease, heart disease, or thyroid disease.
Where it is running
- University of Alabama at Birmingham — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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