Multicenter Prospective Cohort Study on Current Treatments of Legg-Calvé-Perthes Disease

Enrolling by invitation

Conditions studied: Legg Calve Perthes Disease

In brief

Legg-Calvé-Perthes disease is a childhood hip disorder which is common enough to be a significant public health problem (affects 1 in 740 boys between ages 0-14), but uncommon enough to have a sufficient number of patients from a single institution to perform a definitive prospective study comparing the results of current treatments. The present study will establish a database of prospectively identified patients with Legg-Calvé-Perthes (LCP) Disease and collect information regarding their presentation, treatment, and outcomes in the course of receiving currently available treatments. This study seeks to compare the outcomes of current treatments in the management of different age groups (ages 1-6, 6-8, 8-11, \>11) of patients with Perthes disease at two- and five-year followup and at skeletal maturity. For each age group, two to three common treatment regimens currently used by practicing pediatric orthopaedic surgeons will be compared. The intervention a patient receives is determined through physician treatment expertise, and is not pre-determined by the study.

Key facts

Study ID

NCT02040714

Run by

Texas Scottish Rite Hospital for Children

People needed

1500

Starts

2012-08-01

Expected to finish

2032-09-01

Last updated by the study team

2025-05-06

Who can join

Age: 1 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosed with Legg-Calvé-Perthes disease
• Between age 1-18
• Patients with possible secondary femoral osteonecrosis if over the age of 11 due to trauma or corticosteroid therapy are also eligible.

You may not qualify if…

• Patients with previous surgical treatment on the affected hip

Where it is running

• Children's Hospital of Alabama — Birmingham, Alabama, United States
• Children's Hospital of Los Angeles — Los Angeles, California, United States
• Kaiser Permanente Hospital — Los Angeles, California, United States
• Rady Children's Hospital California — San Diego, California, United States
• UCSF Benioff Children's Hospitals — San Francisco, California, United States
• Children's Hospital Colorado — Aurora, Colorado, United States
• Connecticut Children's Medical Center — Hartford, Connecticut, United States
• Alfred I. DuPont Hospital for Children of the Nemours Foundation — Wilmington, Delaware, United States
• Children's National Medical Center — Washington D.C., District of Columbia, United States
• Children's Orthopaedics of Atlanta — Atlanta, Georgia, United States
• Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois, United States
• Johns Hopkins — Baltimore, Maryland, United States
• Children's Hospital Boston — Boston, Massachusetts, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Gillette Children's Specialty Healthcare — Saint Paul, Minnesota, United States
• NYU Langone/Hospital for Joint Disease — New York, New York, United States
• New York Presbyterian Hospital (Columbia Campus) — New York, New York, United States
• Children's Hospital at Montefiore — The Bronx, New York, United States
• OrthoCarolina — Charlotte, North Carolina, United States
• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
• Nationwide Children's Hospital — Columbus, Ohio, United States
• Oklahoma University Health Science Center — Oklahoma City, Oklahoma, United States
• Oregon Health and Science University — Portland, Oregon, United States
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
• University of Tennessee-Campbell Clinic — Germantown, Tennessee, United States

Full record on ClinicalTrials.gov

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