The Effect of Long Duration Exercise on the Diastolic Function of the Heart
Completed · Not applicable
Conditions studied: Aging
In brief
The purpose of this study is to determine whether vigorous exercise training 4-5 days/week for 2 years in sedentary middle aged men and women (ages 45-64) will improve cardiac and vascular compliance to a degree equivalent to life-long exercisers and the sedentary young. Sedentary aging is associated with impaired diastolic function, which can lead to heart failure. However, if exercise training can be implemented early enough in life while cardiovascular plasticity still exists, then functional capacity can be maintained, preventing heart failure.
Key facts
- Study ID
- NCT02039154
- Run by
- University of Texas Southwestern Medical Center
- People needed
- 61
- Starts
- 2012-07-01
- Expected to finish
- 2016-06-01
- Last updated by the study team
- 2020-05-19
Who can join
Age: 45 and older, up to 64. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- healthy, sedentary men and women
- ages 45-64
- body mass index <30
- absence of co-morbid conditions including hypertension, diabetes, heart failure, asthma, chronic obstructive pulmonary disease, coronary artery disease as evidenced by angina or prior myocardial infarction or cerebrovascular disease as evidenced by prior transient ischemic attack or stroke
You may not qualify if…
- healthy, active (aerobic exercisers greater than 2 days per week) men and women
- ages less than 45 or over 64
- body mass index >30
- presence of co-morbid conditions including hypertension, diabetes, heart failure, asthma, chronic obstructive pulmonary disease, coronary artery disease as evidenced by angina or prior myocardial infarction or cerebrovascular disease as evidenced by prior transient ischemic attack or stroke
- Patients with chronic orthopedic injury that might make them unable to participate in an exercise testing will also be excluded
- Subjects unable to speak English will not be recruited because of the complex experimental studies and the need for precise communication between the volunteers and the research staff to ensure safety.
Where it is running
- The Institute for Exercise and Environmental Medicine — Dallas, Texas, United States
Full record on ClinicalTrials.gov
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