A Retrospective Study to Identify New "Omics" Biomarkers of Chronic/Persistent Low Back Pain

Completed

Conditions studied: Persistent/Chronic Low Back Pain

In brief

Low back pain (LBP) is one of the most common medical problems encountered in daily life; it is related to disability and work absence and accounts for high economical costs in Western societies. Low-back pain is a diverse group of mixed pain syndromes (neuropathic and nociceptive) with different molecular pathologies at different structural levels displaying similar clinical manifestations. Currently, there are limited biomarkers (mostly imaging) or clinical findings that can be used objectively to help the physician in precise anatomic diagnosis leading to the safest and most cost-effective treatment for the patient (reduction of direct and indirect costs and improvement of treatment efficacy). The main aim of this trial is to identify all "omics biomarkers" associated with susceptibility to chronic/persistent LBP and its different pathophysiology.

Key facts

Study ID

NCT02037789

Run by

University of Parma

Starts

2014-03-01

Expected to finish

2016-02-01

Last updated by the study team

2016-09-26

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• evidence of clinically unstable disease;
• severe psychiatric disorder (excluding mild depression) or mental impairment;
• recent history ( < 1 year) of spinal fracture;
• pain in the back due to spinal tumor or infection;
• pregnancy

Where it is running

• The Center for Clinical Research (CPI) — Winston-Salem, North Carolina, United States
• Edith Cowan University (ECU) — Perth, Australia
• Multidisciplinary Pain Centre, Hospital Oost-Limburg (ZOL) — Genk, Belgium
• "St.Catharine" Orthopedics, Surgery, Neurology and Physical Medicine and Rehabilitation Specialty Hospital (St-Cat) — Zabok, Croatia
• Anesthesia and Pain Therapy Department, Università degli Studi di Parma (UNIPR) — Parma, Italy
• Fondazione IRCCS Policlinico San Matteo (OSM) — Pavia, Italy

Full record on ClinicalTrials.gov

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