Fatigue and Cardiac Sympathetic Denervation in Parkinson Disease

Completed

Conditions studied: Parkinson's Disease

In brief

The purpose of this research study is to learn about a possible association between cardiac denervation (the breaking down of nerves in the heart) and the development of fatigue in Parkinson's disease (PD).

Key facts

Study ID

NCT02034318

Run by

University of Miami

People needed

25

Starts

2009-03-01

Expected to finish

2015-01-01

Last updated by the study team

2015-03-10

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have been diagnosed with Parkinson's disease within the past 5 years
• Have mild to moderate Parkinson's disease (H\&Y Stage ≤ 3)

You may not qualify if…

• Are currently pregnant or lactating
• Fulfill DSM IV TR criteria for major depression or dysthymia
• Fulfill DSM criteria for generalized anxiety disorder or panic disorder
• Are currently taking a medication known to affect 123I-mIBG uptake (See Appendix 1)
• Have a history of previous relevant cardiac disease, or any clinically significant abnormalities on routine chest radiography, electrocardiography, or cardiac ultrasonography
• Have active lung disease, including asthma, COPD, or pneumonia
• Have diabetes mellitus
• Have congestive heart failure
• Have an active systemic infection
• History of allergic reaction to radionuclide agent or have allergy to iodine

Where it is running

• University of Miami — Miami, Florida, United States

Full record on ClinicalTrials.gov

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