Utilization of Leukocyte Esterase in the Diagnosis of Pediatric Joint Infections

Stopped early

Conditions studied: Joint Infection, Septic Arthritis

In brief

Pediatric joint infections are a common diagnostic dilemma encountered by treating orthopaedic surgeons. No single test is sensitive or specific enough to stand alone in determining the presence of joint infection. The purpose of this study is to test the usefulness of a chemical test strip to detect infection in fluid that is removed from a joint (intra-articular aspiration) in pediatric patients. The test strip measures an enzyme called leukocyte esterase, which has been shown to be useful in detecting the presence of infection in fluids from other parts of the body. This study will assess the efficacy of the leukocyte esterase test as a diagnostic tool for evaluating pediatric joint infections. The hypothesis of the study is that a positive leukocyte esterase test identifies a septic joint in pediatric patients undergoing intraoperative joint aspiration.

Key facts

Study ID

NCT02032732

Run by

University of Tennessee

People needed

9

Starts

2013-12-01

Expected to finish

2016-12-01

Last updated by the study team

2018-11-29

Who can join

Age: 0 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All patients at this facility over the age of 3 months and below the age of 18 years who receive an intra-articular aspiration

You may not qualify if…

• Immunocompromised patients
• Renal failure patients
• Patients younger than 3 months old
• Patients 18 years of age or older
• Volume of aspirate is less than 1.5 mL

Where it is running

• Children's Orthopaedics, Erlanger Health System — Chattanooga, Tennessee, United States

Full record on ClinicalTrials.gov

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