Vascular Endothelial Inflammation and Dysfunction in Pediatric Long-term Cancer Survivors

Completed · Not applicable

Conditions studied: Cancer Survivor, Pediatric Cancer

In brief

Survivors of childhood cancer have an increased risk of death from cardiovascular disease due to both the therapies they received while undergoing treatment and diet and lifestyle factors. The nature of cardiovascular risk and the interaction between treatment affects and cardiovascular risk factors is unknown. We propose to study vascular inflammatory markers as well as measure of blood vessel stiffness (both of which are predictive of early heart disease) in 100 pediatric cancer survivors and 100 control children. Characterization of vascular inflammation and stiffness in long-term survivors will allow for the development of future interventions to decrease inflammation through both pharmacologic and lifestyle modifications.

Key facts

Study ID

NCT02032121

Run by

University of Miami

People needed

6

Starts

2007-10-01

Expected to finish

2015-08-01

Last updated by the study team

2015-09-09

Who can join

Age: 6 and older, up to 30. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 6-30 years of age
• 2 years from the completion of therapy for cancer
• free of active disease

You may not qualify if…

• <6 or > 30 years of age
• current cancer treatment or inside of 2 years post treatment
• Active disease/infection

Where it is running

• University of Miami, MIller School of Medicine — Miami, Florida, United States

Full record on ClinicalTrials.gov

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