A Pilot Study of Dietary Chloride Supplementation on Cardiorenal Function in Heart Failure

Completed · Not applicable

Conditions studied: Heart Failure

In brief

The purpose of this study is to determine if administration of supplemental chloride in the form of lysine chloride to patients with congestive heart failure will affect their neurohormonal profile as well as response to diuretics.

Key facts

Study ID

NCT02031354

Run by

Yale University

People needed

11

Starts

2014-01-01

Expected to finish

2015-03-01

Last updated by the study team

2018-06-27

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years
• Fluency in English
• Heart failure requiring loop diuretic therapy
• Loop diuretic dose ≥ 80mg/day furosemide equivalents
• Stable volume status and diuretic requirement as assessed by treating physician

You may not qualify if…

• Unstable heart failure
• renal replacement therapy or an estimated GFR < 30 ml/min/1.73m2
• Significant bladder dysfunction
• History of hepatic failure
• Pregnancy
• History of hyperinsulinemia/hyperlysinuria

Where it is running

• Yale New Haven Hospital — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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