Intensive Statin Therapy Effect on Post-Operative Atrial Fibrillation (POAF)

Status unconfirmed · Phase 4

Conditions studied: Cardiothoracic Surgery, Post-operative Atrial Fibrillation

In brief

This study will compare the effects of 20 mg of atorvastatin to 80 mg of atorvastatin for the prevention of atrial fibrillation after cardiothoracic surgery. The study hypothesis is that 80 mg of atorvastatin will be more effective at preventing atrial fibrillation compared to 20 mg.

Key facts

Study ID

NCT02029534

Run by

Creighton University

People needed

200

Starts

2013-08-01

Expected to finish

2017-06-01

Last updated by the study team

2016-06-16

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 19 or older
• Undergoing elective cardiothoracic surgery

You may not qualify if…

• Emergency cardiothoracic surgery
• History of permanent atrial fibrillation
• Acute coronary syndrome within 7 days
• Antiarrhythmic drug use in the past 3 months
• Receiving maximal tolerated dose of statin therapy
• Receiving fibrate therapy
• History of statin intolerance
• Significant liver impairment (aspartate aminotransferase/alanine aminotransferase(AST/ALT)>2x ULN)
• Serum Creatinine > 3 mg/dl
• Pregnancy or breastfeeding

Where it is running

• Creighton University — Omaha, Nebraska, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.