Nebulized 3% Hypertonic Saline in the Treatment of Acute Bronchiolitis

Completed · Not applicable · Has a placebo group

Conditions studied: Acute Bronchiolitis

In brief

This is a randomized, double-blind, controlled trial in the Pediatric Emergency Department. The primary objective is to determine whether nebulized 3% hypertonic saline is more effective than nebulized 0.9% saline in the treatment of bronchiolitis in the emergency department.

Key facts

Study ID

NCT02029040

Run by

University of Texas Southwestern Medical Center

People needed

52

Starts

2013-12-01

Expected to finish

2014-12-01

Last updated by the study team

2019-01-25

Who can join

Age: 0 and older, up to 1. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Children 2-12 months of age presenting to Emergency Department
• Patients with a diagnosis of bronchiolitis defined as the first episode of wheezing and/or crackles in a child younger than 12 months who has physical findings of a viral respiratory infection and has no other explanation for the wheezing and/or crackles
• Patients with an RDAI score ≥ 6 as measured by a trained respiratory therapist

You may not qualify if…

• Previous history of wheezing
• Known heart or lung disease
• Premature birth defined as birth before 37 weeks gestation
• Immunosuppression or immunodeficiency
• Treatment with corticosteroids in the previous 48 hours
• Critically ill children - progressive respiratory failure requiring higher level of care, vital signs instability/need for emergency interventions to prevent clinical deterioration
• Oxygen saturation <85% on room air at the time of recruitment

Where it is running

• UT Southwestern Medical Center; Children's Medical Center — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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