Metformin and Furosemide Drug-Drug Interaction Study

Completed · Phase 1

Conditions studied: Healthy

In brief

This study will assess the potential effects of lesinurad on the pharmacokinetics (PK) of metformin and furosemide in healthy, adult male subjects.

Key facts

Study ID

NCT02028689

Run by

Ardea Biosciences, Inc.

People needed

23

Starts

2013-10-01

Expected to finish

2014-01-01

Last updated by the study team

2014-02-14

Who can join

Age: 18 and older, up to 55. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Subject has a body weight ≥ 50 kg (110 lbs) and body mass index ≥ 18 and ≤ 30 kg/m2.
• Subject is free of any clinically significant disease or medical condition, per the Investigator's judgment.

You may not qualify if…

• Subject has a history or suspicion of kidney stones, prostatic hyperplasia, or urinary stricture.
• Subject has undergone major surgery within 3 months prior to Screening.
• Subject donated blood or experienced significant blood loss (>450 mL) within 12 weeks prior to Screening or gave a plasma donation within 4 weeks prior to Screening.
• Subject has inadequate venous access or unsuitable veins for repeated venipuncture.

Where it is running

• Study site — Kalamazoo, Michigan, United States

Full record on ClinicalTrials.gov

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