Cocaine Opioid Oxytocin Option - Limited

Completed · Phase 1 · Has a placebo group

Conditions studied: Opioid Use Disorder, Cocaine Use Disorder

In brief

This is a pilot feasibility study assessing the tolerability of chronic administration of intranasal oxytocin to patients receiving methadone at an opioid replacement clinic who are actively using cocaine.

Key facts

Study ID

NCT02028533

Run by

University of California, San Francisco

People needed

30

Starts

2014-07-01

Expected to finish

2014-12-01

Last updated by the study team

2019-05-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Enrolled as a patient in the San Francisco General Hospital Opioid Treatment Outpatient Program
• Stable dose of methadone for at least the past two weeks
• At least one routine urine toxicology screen positive for cocaine in the past month

You may not qualify if…

• Positive urine pregnancy test
• Use of illicit drugs in the past month (with the exception of cocaine or cannabis)
• Currently meets Diagnostic and Statistical Manual-5 (DSM-V) criteria for severe major depressive disorder with suicidal thoughts or actions
• History of psychotic or moderate-severe alcohol use disorder as defined by DSM-V criteria
• Severe neuropsychological disorder, brain trauma, epilepsy
• Sensitivity to preservatives (in particular E 216, E 218 and chlorobutanol hemihydrate)
• Nasal obstruction, discharge, or bleeding
• Habitually drinks large volumes of water
• Taking testosterone, estrogen/progesterone supplement, or serotonin-1a receptor agonists/antagonists

Where it is running

• San Francisco General Hospital Opiate Treatment Outpatient Program — San Francisco, California, United States

Full record on ClinicalTrials.gov

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