Prevention of Infection in Closed Fractures: Cefazolin Versus Vancomycin

Stopped early · Not applicable

Conditions studied: Infection, Closed Fractures

In brief

The purpose of this study is to compare the incidence rate of infection in surgical patients with closed fractures treated prophylactically with Cefazolin versus Vancomycin in the peri-operative period. The hypothesis of this study is that patients undergoing surgical treatment for closed fractures who are treated prophylactically with Vancomycin will have a lower incidence rate of infection than patients who are treated prophylactically with Cefazolin.

Key facts

Study ID

NCT02027532

Run by

University of Tennessee

People needed

430

Starts

2009-10-01

Expected to finish

2017-12-01

Last updated by the study team

2018-07-11

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Between 18 years old and 85 years old
• Closed fracture
• Fracture treatment plan is for one operation on one day (one surgical setting)
• Likely to follow-up with surgeon until fracture is healed
• Ability to understand and agree to Informed Consent

You may not qualify if…

• Under 18 years old or over 85 years old
• Open fracture(s)
• Fracture requires multiple operations
• Other injuries requiring operations
• Documented allergy to Cefazolin or Vancomycin
• Previous history of Methicillin-resistant Staphylococcus aureus infection
• Previous surgery on the injured extremity within 1 year
• Use of antibiotics within 2 weeks before or after injury
• Use of antibiotics within 2 weeks before surgery
• Unlikely to follow-up until fracture is healed
• Unable to understand and agree to Informed Consent

Where it is running

• Erlanger Health System — Chattanooga, Tennessee, United States

Full record on ClinicalTrials.gov

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