Persistence of Varicella Immunity in Hospital Employees Receiving Varicella Vaccine

Withdrawn before enrolling · Phase 4

Conditions studied: Persistence of Varicella Immunity

In brief

The purpose of the study is to learn more abou how the immune system responds to the chickenpox vaccine in adults who had never had chickenpox as a child and were then vaccinated as an adult. The study aims to learn more about the strength and duration of the protection provided by the vaccine in adults, and to observe the immune response to an additional dose of chickenpox vaccine in adults who had received the vaccine at least 5 years earlier. This is especially relevant to workers in a hospital who may be exposed to chickenpox.

Key facts

Study ID

NCT02026089

Run by

University of Colorado, Denver

People needed

0

Starts

2021-12-01

Expected to finish

2022-06-01

Last updated by the study team

2021-02-09

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18-80
• Group 1: * Evaluated in Occupational Health Clinic (OHC) for employment from 2004-2009 and found to be seronegative for varicella.
• Received at least one varicella vaccination to meet employment criteria at least 5 year prior to enrollment.
• Subject is afebrile (<100.4F oral) on day of vaccination.
• Group 2: * Evaluated in OHC for employment from 2004 -2009 and found to be seropositive for varicella.

You may not qualify if…

• Immune suppressed or receiving immune suppressive treatment
• Pregnant, breastfeeding or plan to become pregnant within 6 weeks after receiving varicella vaccine.
• Receiving antiviral medications active against varicella virus within 3 days before varicella vaccination until 10 days after varicella vaccination.
• Receipt of any vaccine within 2 weeks before enrollment or expected receipt within 6 weeks after vaccination.
• Receipt of any immunoglobulins or blood products within 5 months prior to study enrollment or expected receipt prior to last visit.
• History of hypersensitivity reaction to any vaccine component (including gelatin), or an anaphylactic/anaphylactoid reaction to neomycin.
• History of chickenpox or shingles since pre-employment serology testing.
• Receipt of any additional varicella or zoster vaccine since vaccination under hospital policy and procedure guidelines.
• Currently participating in any other studies with an investigational compound within 30 days of signing the consent and throughout participation in the study.

Where it is running

• Children's Hospital Colorado — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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