RNAseq Analysis of Microbial Gene Expression in Necrotizing Soft Tissue Infections

Completed

Conditions studied: Necrotizing Soft Tissue Infections

In brief

Hypothesis: We hypothesize that RNAseq will allow us to learn more about the causative agents of necrotizing soft tissue infections (NSTI) and risk factors involved in acquiring these devastating infections Tissue biopsies will be obtained from consented patients admitted with NSTI. Biopsies will be used for standard clinical analysis of bacterial species present or stored for later RNA sequencing. RNA sequencing will identify bacteria that are present within the infection site that may not be detected using standard culture techniques as well as reveal bacterial gene expression profiles within the NSTI site. Medical charts will also be reviewed for basic patient information as well as wound care management practices. We hope to identify bacterial species commonly present in these types of infections as well as risk factors predisposing individuals to NSTI's.

Key facts

Study ID

NCT02025816

Run by

Texas Tech University Health Sciences Center

People needed

35

Starts

2013-12-01

Expected to finish

2019-06-01

Last updated by the study team

2019-12-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient or LAR agrees to the procedure and signs informed consent form
• Patient is at least 18 yrs of age
• Patient has been diagnosed with an NSTI

You may not qualify if…

• Patient not willing to undergo additional tissue biopsies for RNA sequencing analysis

Where it is running

• Texas Tech University Health Sciences Center/University Medical Center — Lubbock, Texas, United States
• University Medical Center — Lubbock, Texas, United States

Full record on ClinicalTrials.gov

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