Phenylephrine Versus Ephedrine in Pre-eclampsia

Stopped early · Phase 4

Conditions studied: Pre-eclampsia

In brief

Phenylephrine administration is associated with reductions in CO and SctO2 compared with ephedrine when used for blood pressure management in women with pre-eclampsia undergoing cesarean delivery under spinal anesthesia.

Key facts

Study ID

NCT02025426

Run by

Duke University

People needed

13

Starts

2012-09-01

Expected to finish

2016-07-08

Last updated by the study team

2020-10-14

Who can join

Age: 18 and older, up to 50. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• English speaking
• Age ≥18 yrs
• Pre-eclampsia (mild, or severe)
• Non-laboring women
• CD under spinal anesthesia

You may not qualify if…

• Height < 5'0"
• Allergy to phenylephrine or ephedrine, or any other standardized medication
• Severe Cardiac disease in pregnancy with marked functional limitations (NYHA Class III and IV)
• Patients on Monoamine Oxidase Inhibitors or Tricyclic Antidepressants
• History of recent amphetamine or cocaine use.
• Subject enrollment in another study involving a study medication within 30 days of CD
• Any other physical or psychiatric condition which may impair their ability to cooperate with study data collection

Where it is running

• Duke University Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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