Sodium Nitrite to Treat Arterial Aging
Completed · Phase 1/Phase 2 · Has a placebo group
Conditions studied: Vascular Aging
In brief
The proposed research will determine the effectiveness of nitrite, a naturally occurring compound in the body, for improving the health and function of arteries in middle-aged and older adults. The study also will provide insight into how sodium nitrite therapy improves artery health by determining the physiological mechanisms (biological reasons) involved. Overall, the proposed research will provide important new scientific evidence on the effectiveness of sodium nitrite for decreasing the risk of developing cardiovascular diseases with aging.
Key facts
- Study ID
- NCT02022670
- Run by
- University of Colorado, Boulder
- People needed
- 33
- Starts
- 2011-10-01
- Expected to finish
- 2013-12-01
- Last updated by the study team
- 2015-07-15
Who can join
Age: 50 and older, up to 79. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- 50-79 years of age
- Ability to provide informed consent
- Score greater than 22 on the mini mental state exam
- Blood pressure greater than 100/60 mmHg for past 3 months
You may not qualify if…
- Are taking any of the following medications/drugs: hormone replacement therapy, anti-hypertensives, nitrates, nervous system depressants, allopurinol, phosphodiesterase-5 inhibitors, blood thinners
- Are currently sick/have chronic clinical diseases such as kidney disease, diabetes, or unstable cardiovascular disease
- Are hypersensitive to nitrates or nitrites
- Have glucose-6-phosphate dehydrogenase deficiency
- Have blood methemoglobin greater than 2%
- Have a BMI greater than 40 kg/m\^2
- Have a baseline FMD of greater than 6%
- Have not been post-menopausal for at least 1 year
- Perform regular vigorous aerobic/endurance exercise
Where it is running
- Clinical Translational Research Center — Boulder, Colorado, United States
Full record on ClinicalTrials.gov
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