Study of Dietary Additive Phosphorus on Proteinuria and Fibroblast Growth Factor-23
Completed · Not applicable
Conditions studied: Albuminuria
In brief
Phosphorus-based food additives are commonly used by food manufacturers for many applications, such as enhancing flavor, in ready-to-eat foods and beverages. While these additives can significantly increase an individual's daily phosphorus intake, little is known about the effect of dietary phosphorus on kidney health. In this study, the investigators will first lower baseline phosphorus intake to about 1000mg/d by educating participants to avoid foods with phosphorus additives. Then, participants will be randomized to a higher phosphorus period (\~2gm/d) and a lower phosphorus period (\~1gm/d) by providing unaltered, commercially-available food/beverage products with and without phosphorus additives. The investigators hypothesize that participants will have higher urine albumin excretion and fibroblast growth factor-23 (FGF-23) during the higher phosphorus period compared to the lower phosphorus period.
Key facts
- Study ID
- NCT02020785
- Run by
- Geisinger Clinic
- People needed
- 31
- Starts
- 2014-01-01
- Expected to finish
- 2015-09-01
- Last updated by the study team
- 2019-06-05
Who can join
Age: 21 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults at least 21 years of age with at least microalbuminuria
You may not qualify if…
- Estimated glomerular filtration rate <45ml/min/1.73m2, poorly controlled diabetes or hypertension, nephrotic syndrome, hyperparathyroidism, Paget's Disease, multiple myeloma, uncontrolled thyroid disease, chronic antacid use, use of phosphorus binders, phosphorus supplements, or high-dose vitamin D, inability to complete feeding study, investigator discretion
Where it is running
- Prohealth Clinical Research Unit — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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