Regional Prophylactic Vancomycin in Revision Total Knee Replacement

Completed · Phase 2/Phase 3

Conditions studied: Arthropathy of Knee Joint

In brief

The purpose of this study is to determine whether or not giving a lower dose of antibiotics (Vancomycin) in the area where it is needed (the knee joint) is more effective at preventing infection than the current standard dose which is given intravenously (IV) through a wrist vein.

Key facts

Study ID

NCT02020031

Run by

Mayo Clinic

People needed

22

Starts

2013-12-01

Expected to finish

2015-06-01

Last updated by the study team

2016-11-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Revision total knee arthroplasty
• Informed consent given

You may not qualify if…

• Current treatment with IV Vancomycin within the preceding 7 days
• Previous hypersensitivity to vancomycin
• Significant cardiac or respiratory abnormality
• Contraindications to using the intraosseous vascular access system (EZ-IO)
• Sepsis

Where it is running

• Mayo Clinic — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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