A Pilot Study Testing Onabotulinum Toxin A Versus Incobotulinum Toxin A Injections for Facial Wrinkles

Running, not enrolling · Early Phase 1

Conditions studied: Wrinkles

In brief

The purpose of this study is to compare the effectiveness of Botox® (Onabotulinum Toxin A) versus Xeomin® (incobotulinum toxin A) for the treatment of forehead and glabellar (vertical lines between the eyebrows) wrinkles.

Key facts

Study ID

NCT02019004

Run by

Northwestern University

People needed

20

Starts

2013-11-01

Expected to finish

2027-12-01

Last updated by the study team

2026-07-01

Who can join

Age: 20 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Females and males
• In good health
• Is 20-65 years of age
• Has static and moderate dynamic forehead/glabellar wrinkles
• Has willingness and the ability to understand and provide informed consent and communicate with the study staff

You may not qualify if…

• Pregnant or lactating
• Younger than 20 or older than 65 years of age
• Has received the following treatments in the forehead or glabellar region:
• botulinum toxin injections in the past 6 months
• ablative laser procedure in the past 6 months
• radiofrequency device treatment in the past 6 months
• ultrasound device treatment in the past 6 months
• medium to deep chemical peel in the past 6 months
• temporary soft tissue augmentation material in the area to be treated in the past year
• semi-permanent soft tissue augmentation material in the area to be treated in the past 2 years
• permanent soft tissue augmentation material in the area to be treated
• Is planning to receive within the next 6 months, any cosmetic procedure (such as any chemical peels, botulinum toxin injections, ablative or non-ablative laser procedures, filler injections, radiofrequency procedures, dermabrasion, ultrasound and face lifting procedures) in the forehead or glabellar region.
• Is planning to use tretinoin or retinoic acid in the next 6 months
• Has an active infection in the forehead or glabellar region (excluding mild acne)
• Is allergic to cow's milk protein
• Is allergic to albumin
• Taking aminoglycoside
• Is currently using anticoagulation therapy
• Has a history of bleeding disorders
• Has a mental illness
• Unable to understand the protocol or to give informed consent

Where it is running

• Northwestern University Department of Dermatology — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.