Effect of Liraglutide on Epicardial Fat in Subjects With Type 2 Diabetes
Completed · Phase 4
Conditions studied: Type 2 Diabetes, Overweight, Obesity
In brief
The purpose of this research study is to learn about the effect of Liraglutide, (Victoza®), on the fat surrounding the heart.Excessive amount of the fat around the heart is common in people with type 2 diabetes and can be associated with poor sugar control. Liraglutide is an injectable prescription medicine that can improve blood sugar control in adults with type 2 diabetes.
Key facts
- Study ID
- NCT02014740
- Run by
- University of Miami
- People needed
- 100
- Starts
- 2014-03-01
- Expected to finish
- 2017-03-01
- Last updated by the study team
- 2019-06-06
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Type 2 diabetes, as defined by ADA criteria
- HbA1c < 8% measured at least 1 month prior to this study
- BMI ≥27 kg/m2
- Pre-treatment with Metformin
- Age > 18 and < 65 years old
You may not qualify if…
- • Known contra-indications to Liraglutide, such as previous history of pancreatitis or medullary thyroid carcinoma, personal or family history of MEN, in accordance with risks and safety information included in the latest updated Prescribing Information for Victoza®
- Type 1 diabetes, as defined by American Diabetes Association (ADA) criteria
- Insulin dependent or treated type 2 diabetes
- Current use of other injectable incretins
- History of diabetes ketoacidosis
- Advanced Chronic Kidney Disease, as defined by Glomerular Filtration Rate (GFR) < 30 mL/min/1.73m2
- Clinical signs or symptoms of New York Heart Association (NYHA) class III-IV heart failure
- Clinical or laboratory evidences of chronic active liver diseases
- Acute or chronic infective diseases
- Cancer or chemotherapy
- Current use of systemic corticosteroids or in the 3 months prior this study
- Known or suspected allergy to Liraglutide, excipients, or related products
- Pregnant, breast-feeding or the intention of becoming pregnant
- Females of childbearing potential who are not using adequate contraceptive methods
Where it is running
- University of Miami — Miami, Florida, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.