Muscle Ultrasound Signifies Condition Upgrade Leading Approach to Recovery

Completed

Conditions studied: Acute Respiratory Failure, Critical Illness

In brief

Examination of serial muscle ultrasounds and muscle sampling within the population of ICU patients who require mechanical ventilation for acute respiratory failure, will lead to the ability of investigators to link specific baseline comorbidities, drugs, or fluid administrations, to the onset and duration of architectural changes within muscle and correlate ultimately with muscle function. With this study, we will be better able to understand the relationships between the pattern of resolution of the muscle architectural abnormalities within the context of multiple other clinical abnormalities and therapies present and rendered to ICU patients.

Key facts

Study ID

NCT02014285

Run by

Wake Forest University Health Sciences

People needed

1

Starts

2012-11-01

Expected to finish

2017-05-03

Last updated by the study team

2017-11-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age > 18 years
• Mechanically ventilated via an endotracheal tube or mask
• New diagnosis of Acute Lung Injury or Sepsis

You may not qualify if…

• Upon Principle Investigator discretion, patient not suitable for study
• Moribund
• Other Research Study without co-enrollment permissions
• Pregnancy
• Primary neuropathies
• Amputees
• Inability to walk without assistance prior to diagnosis (use of cane or walker not exclusion)
• Preadmission immunocompromised state (HIV, >20mg prednisone/day, other immunosuppressive therapy)
• BMI >45 (difficulty obtaining biopsy)
• Underlying neuromuscular disease
• Acute stroke
• Hip fracture, unstable C spine, or pathological fracture
• Current hospitalization or transferring hospital stay >80 hours
• CPR previous to consent without signs of full neurologic recovery
• Previous hospitalization within past 30 days
• Cognitive impairment prior to ICU illness
• Re-admission to ICU within current admission
• Cancer therapy within the last 12 months
• Full dose anticoagulation therapy
• Known platelet count <100,000
• Known INR >1.5
• Known aPTT >1.5 upper limit of normal
• Patient on antiplatelet therapy (daily aspirin therapy is acceptable)

Where it is running

• Wake Forest University Health Sciences — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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