Nutrition for Migraine Prevention

Completed · Not applicable

Conditions studied: Migraine Disorders

In brief

Migraine is a widespread, debilitating, chronic pain disorder and a major public health challenge. Most conventional, pharmaceutical treatments fail to give satisfactory long-term relief and their repeated use can have important side effects. This project involves implementation of substantial dietary changes in adults with migraine. Our goal is to test the hypothesis that a causal relationship exists between migraine symptoms and the amount and proportions of foods consumed containing defined amounts of polyunsaturated fatty acids. Significant findings supporting the hypothesis will lead to a major shift in both prevention and management of migraine and other chronic pain disorders. Emphasis is on low-cost, health improvement strategies utilizing specific dietary modifications for pain management, based on solid clinical research evidence.

Key facts

Study ID

NCT02012790

Run by

University of North Carolina, Chapel Hill

People needed

182

Starts

2014-07-01

Expected to finish

2018-05-11

Last updated by the study team

2020-10-06

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years of age or older
• Either gender
• Meets 2004 International Classification of Headache Disorders-II* criteria for Episodic Migraine
• Frequent migraine headaches
• Headache history: > 2 years leading up to study meeting migraine criteria
• Willing to complete daily diary for 26 weeks
• Able to attend 8 dietitian counseling sessions
• Under care of a physician for headaches
• Able to read and communicate in English

You may not qualify if…

• Marked depression, anxiety or psychosis.
• History of specific food allergies, such as, but not limited to, dairy or gluten products
• Pregnancy or anticipated pregnancy
• Active treatment for a major medical illness, such as malignancy, autoimmune, immune deficiency disorder, etc.
• History of significant head trauma or head/neck surgery within the past 3 years
• History of subarachnoid or intra-cerebral hemorrhage or subdural hematoma
• Allergy to fish or strong aversion to fish consumption.
• History of nervous system infection such as meningitis or encephalitis within the preceding 5 years
• History of vasculitis, intracranial mass, clotting disorder
• Cognitive dysfunction that would prevent informed consent

Where it is running

• UNC Program on Integrative Medicine — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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