Inspired Helium for Ischemic Protection During Knee Replacement Surgery

Completed · Phase 1

Conditions studied: Ischemia

In brief

The purpose of this study is to determine whether breathing in helium reduces indications of injury to the skeletal muscle seen in blood tests after knee replacement surgery. The ability to reduce the risk of skeletal muscle injury may help improve patient safety by providing protection to the area of the body having its blood supply interrupted during a particular surgery.

Key facts

Study ID

NCT02012361

Run by

University of Florida

People needed

40

Starts

2014-10-01

Expected to finish

2016-08-01

Last updated by the study team

2019-08-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Scheduled for an elective total knee arthroplasty
• > 18 years of age
• Expected to require inhaled oxygen concentrations < 25%
• Able to provide informed consent

You may not qualify if…

• Expected to require inhaled oxygen concentrations > 25%
• < 18 years of age
• Member of a defined vulnerable population (e.g. pregnant, mentally handicapped, prisoners, etc.).

Where it is running

• UF Health — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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