Metabolism And Health Effects Of Citrus Limonoids in Hypercholesterolemic Humans
Completed · Not applicable · Has a placebo group
Conditions studied: Hypercholesterolemia
In brief
Limonoids are compounds found in citrus juices, seeds and peel. Some research shows that they reduce blood cholesterol and also reduce the incidence of several forms of cancer. Although these compounds are part of the natural human diet, the dose required to provide health benefits and the risks associated with the intake of high doses by humans have not been studied. This study will examine metabolism, safety, lipid-lowering and anti-inflammatory effects of limonoids. The dose of limonoids in this study is equivalent to that found in six 8 oz glasses of orange juice per day. The investigators hypothesize that limonin glucoside supplementation will reduce total cholesterol, LDL cholesterol, ratio of LDL and HDL cholesterol, number of LDL particles, and serum markers of inflammation.
Key facts
- Study ID
- NCT02011789
- Run by
- USDA, Western Human Nutrition Research Center
- People needed
- 10
- Starts
- 2007-04-01
- Expected to finish
- 2010-07-01
- Last updated by the study team
- 2013-12-13
Who can join
Age: 20 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Hypercholesterolemic, total blood cholesterol 200-300 mg/dL
- BMI 20-35 kg/m2
- normal Complete Blood Count
- normal serum transaminases, alkaline phosphatase, and creatinine
- normal thyroid function
- LDL cholesterol > 130 mg/dL
- Triglyceride < 300 mg/dL
- serum C-Reactive Protein 1.0-25 mg/L
You may not qualify if…
- current pregnancy or lactation
- smoking
- use of alcohol > 1 drink per day (1 oz distilled liquor, 3 oz wine, 12 oz beer)
- reported history of cardiovascular disease or chronic inflammatory diseases
- current users of oral contraceptives
- lipid-lowering, anti-inflammatory, anti-coagulant, or thyroid medications
- currently drinking more than 4 glasses per day of orange or grapefruit juice
Where it is running
- USDA Western Human Nutrition Research Center — Davis, California, United States
Full record on ClinicalTrials.gov
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