Validation of Coronary Calcium Subtraction to Improve Diagnostic Accuracy of Coronary CT Angiography

Completed

Conditions studied: Coronary Artery Disease

In brief

Coronary calcium hampers accurate evaluation of the coronary arteries with coronary computed tomography angiography (CCTA). A novel approach to potentially overcome this limitation is coronary calcium subtraction. The primary hypothesis of the study is: \- Coronary calcium subtraction CCTA will improve diagnostic accuracy as compared to conventional CCTA on a per-patient basis

Key facts

Study ID

NCT02011061

Run by

Rigshospitalet, Denmark

People needed

182

Starts

2013-10-01

Expected to finish

2016-06-01

Last updated by the study team

2021-01-07

Who can join

Age: 55 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age > 55 Years
• Scheduled for invasive coronary angiography
• Logistically possible to perform CCTA before invasive evaluation

You may not qualify if…

• Known Iodine-contrast allergy
• Estimated GFR below 50 ml/min
• Atrial fibrillation or other persistence cardiac arrythmia
• Contraindication to betablockers (bronchospasm, LVEF less than 40%)
• Implanted PM or ICD
• Previous mechanical heart valve surgery
• Inability to maintain breath-hold for at least 5 sec
• Patient-related condition resulting the inability of the patient to understand the informed consent form of the study

Where it is running

• National Heart, Lung and Blood Institute — Bethesda, Maryland, United States
• Department of Cardiology and Radiology, Rigshospitalet, The Heart Center, Capital Region of Copenhagen, University of Copenhagen — Copenhagen, Denmark

Full record on ClinicalTrials.gov

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